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杭白菊的道地性和药理作用研究进展

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目的 针对杭白菊的道地性和药理作用相关文献进行综述和分析,旨在为杭白菊的新药开发和功能性食品开发提供方向和依据。方法 通过检索中国知网、万方、PubMed数据库,对杭白菊国内外已发表的有关道地性和药理作用的文献进行整理,通过对杭白菊不同产区的活性成分差异研究,初步分析其道地优势的潜在药效物质基础,并着重综述其药理作用和机制的研究进展,为后续研究和开发的方向提供建议。结果 杭白菊是"浙八味"之一,是浙江桐乡地区的道地药材,其道地优势可能与其中的黄酮类、多酚类成分和挥发油含量有关,杭白菊的药理作用研究主要集中在其抗氧化、抗炎、视网膜保护、心血管保护、降糖、降脂、神经保护、肝肾和胃肠道保护等作用。结论 本研究对杭白菊的道地性进行了整理,为其桐乡产区的道地性提供证据,并重点对其药理作用的研究进展进行综述,为更深入地阐明其药理作用机制提供参考和建议,也为以杭白菊为原料的新型药物和功能性食品提供了开发方向。
Research Progress on Authenticity and Pharmacological Activities of Chrysanthemum Morifolium Ramat Cv.'Hangbaiju'
OBJECTIVE To review and analyze the literature related to the authentic property and pharmacological effects of Chrysanthemum morifolium Ramat cv.'Hangbaiju',in order to provide the direction and basis for the development of new drugs and functional food.METHODS By searching CNKI,Wanfang and PubMed databases,the published literatures on the authenticity and pharmacological effects of Chrysanthemum morifolium Ramat cv.'Hangbaiju'at home and abroad were sorted out,based on the study of the difference of active ingredients in different producing areas,the pharmacodynamic material basis of Chrysanthemum morifolium Ramat cv.'Hangbaiju'was preliminarily analyzed,and the research progress of its pharmacological action and mechanism was reviewed,and suggestions were provided for the direction of follow-up research and development.RESULTS As one of the"Zhebawei",Chrysanthemum morifolium Ramat cv.'Hangbaiju'was an authentic herbal medicine in Tongxiang area of Zhejiang province.Its authentic advantages might be related to the contents of flavonoids,polyphenols and volatile oils in it.Pharmacological effects of Chrysanthemum morifolium Ramat cv.'Hangbaiju'mainly focused on its antioxidant,anti-inflammatory,retinal protection,cardiovascular protection,hypoglycemic,lipid-lowering,neuroprotective,liver and kidney protection and gastrointestinal protection.CONCLUSION In this paper,the research progress on the authenticity and pharmacological effects of Chrysanthemum morifolium Ramat cv.'Hangbaiju'is summarized,which provides evidence for its authenticity in Tongxiang production area,provides references and suggestions for further elucidating its pharmacological mechanism,and also provides the development direction for new drugs and functional foods using Chrysanthemum morifolium Ramat cv.'Hangbaiju'as raw materials.

Chrysanthemum morifoliumeight Zhejiang genuine medicinal materials(Zhebawei)pharmacological effects

吕丽丽、俞佳玉、潘红烨、周佳锋、姚建标

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浙江康恩贝制药股份有限公司,杭州 310052

浙江省中药制药技术重点实验室,杭州 310052

杭白菊 浙八味 药理作用

浙江省科技计划项目

2023C03004

2024

中国现代应用药学
中国药学会

中国现代应用药学

CSTPCD北大核心
影响因子:0.877
ISSN:1007-7693
年,卷(期):2024.41(14)