OBJECTIVE To study the the synthetic process of imidazole antifungal drug lanoconazole.METHODS Lanoconazole was synthesized using 2-Chloromandelic acid as the starting material,via esterification,halogenation,reduction,methylsulfonyl esterification to get compound 4D,followed by reaction with 1-imidazolyl acetonitrile,carbon disulfide and potassium hydroxide to get dipotassium salt compound 3,cyclization,configuration conversion,separation and recrystallization to get lanoconazole.RESULTS The total yield was 36.5％based on 2-Chloromandelic acid.The structures of lanoconazole and key intermediates in the process were confirmed by MS and 1H-NMR.CONCLUSION The synthetic process is simple in operation and suitable for industrial production with cheap and readily available raw materials and less waste.
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