Progress on the Mechanism of Action of Flavonoids from Traditional Chinese Medicine in Cell Programmed Death-mediated Bone and Joint Diseases
The occurrence of bone and joint diseases shows a trend in youth,and the prevalence is gradually increasing.The common diseases include osteoporosis,osteoarthritis,rheumatoid arthritis,and so on.Programmed cell death(PCD)is a common phenomenon in living organisms,which is related to the growth and development of organisms,tissue repair,and disease development,which includes apoptosis,pyroptosis,autophagy,ferroptosis,necroptosis,cuproptosis and neutrophil extracellular traps-osis(NETosis).Previous studies have been confirmed that the activation or inhibition of PCD plays a crucial role in bone and joint diseases.In recent years,treatment of bone and joint diseases using active components of flavonoids in traditional Chinese medicine(TCM)has raised concern.Pharmacological research has demonstrated that flavonoids play a role in functional cells of bone by inhibiting or inducing PCD.This paper reviewed literature on the treatment of bone and joint diseases with flavonoid components of TCM at home and abroad in recent years,then summarized the mechanisms of apoptosis,autophagy,pyroptosis,and ferroptosis of mesenchymal stem cells,osteoblasts,chondrocytes and osteoclasts.This review aims to offer a novel perspective and methodology for elucidating the mechanisms underlying the efficacy of TCM in the treatment of bone and joint diseases.Additionally,it seeks to establish a foundation for the clinical application of TCM in the prevention and management of bone and joint diseases.
programmed cell deathbone and joint diseasestraditional Chinese medicineflavonoids
万方数据
维普
