Pharmacokinetic Parameters Calculation and Bioequivalence Analysis Based on SAS,R and WinNonLin Software
OBJECTIVE To calculate pharmacokinetic parameters and bioequivalence analysis through SAS,R,and WinNonL in software.METHODS The SAS"proc reg"and"proc mixed"procedures,the R"NonCompart"and"nlme"packages,and WinNonLin software were used to calculate pharmacokinetic parameters and construct a linear mixed-effects model.Used two one-sided t-tests and the 90％confidence interval to determine bioequivalence.RESULTS The pharmacokinetic parameters and bioequivalence results calculated using SAS,R and WinNonLin software were consistent.CONCLUSION The pharmacokinetic parameters calculation and bioequivalence analysis can be achieved through SAS,R,and WinNonLin software with accurate and reliable result.
万方数据
维普
