首页|细胞膜纳米载药系统研究进展及其在仿生纳米医学中的应用

细胞膜纳米载药系统研究进展及其在仿生纳米医学中的应用

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传统药物的局限和纳米药物的兴起推动了仿生纳米医学的发展,细胞膜纳米技术是仿生纳米医学领域的一种新型技术,它将纳米核心颗粒包裹在所提取的细胞膜中,这种结构保留了源细胞的表面特性,具有靶向运输能力强、血液循环时间长和免疫逃避等优势,因此细胞膜纳米技术在仿生医学领域的应用越来越广泛。目前研究较多的有红细胞膜、白细胞膜、血小板膜、肿瘤细胞膜、干细胞膜以及细菌外膜囊泡等,每种膜都有着自己独特的优势,并且在药物递送、免疫调节、抗肿瘤治疗和疫苗制备等领域都有着较大的发掘潜力。
Advances of Cell Membrane Nanodrug-carrying Systems and Its Applications in Biomimetic Nanomedicine
The limitation of traditional drugs and the rise of nano medicines drive the development of bionanomedicine.The technology of cell membrane camflouged nanoparticles is a new type of research in the field of bionanomedicine,it encapsulates the nanocore particles in the extracted cell membrane,this structure retains the surface properties of the source cell,which has the advantages of strong target transport ability,long blood circulation time,and immune evasion.Therefore,the nanotechnology of cell membrane is increasingly used in the medical field.Currently,the most studied ones are erythrocyte membrane,leukocyte membrane,platelet membrane,tumor cell membrane,stem cell membrane,and bacterial outer membrane vesicles.Each membrane has its unique advantages and has a large potential to be explored in areas such as drug delivery,immunomodulation,antitumor therapy,and vaccine preparation.

biomimetic medicinecell membrane-camouflaged nanoparticlesdrug deliverytargeting transport

姚岑超、王珩、张大宏

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浙江中医药大学第二临床医学院,杭州 310053

浙江省人民医院泌尿外科,杭州 310014

仿生医学 细胞膜包被纳米 药物递送 靶向运输

2024

中国现代应用药学
中国药学会

中国现代应用药学

CSTPCD北大核心
影响因子:0.877
ISSN:1007-7693
年,卷(期):2024.41(19)