Practice Guidelines for the Off-label Use of Antibodies Targeting Lymphocyte
OBJECTIVE To provide a reference for the off-label use of antibodies targeting lymphocytes and to promote the rational clinical use of this type of drug.METHODS A multidisciplinary team of experts was established and the guidelines were developed through many rounds of expert discussion based on evidence-based medicine.RESULTS A total of 148 items on off-label use supported by sufficient evidence were included,including 4 items on CD3 and CD 19 bispecific antibodies,103 items on CD20 antibodies,23 items on antibody-drug conjugate(ADC)targeting CD30,17 items on CD38 antibodies and 1 item on ADC targeting CD79b.CONCLUSION This guideline clarifies the off-label use of antibodies targeting lymphocytes with sufficient evidence,and provides a practical reference for the off-label use of this type of drug.
antibodies targeting lymphocytespractice guidelinesoff-label userational use of drugsmedication management
万方数据
维普
