In order to select the suitable fertilization practices in the gravel removal field,using field comparative experi-ments,the effects of no fertilizers(CK),water-soluble macronutrient fertilizer,water-soluble macronutrient fertilizer+biological bacterial manure,and biogas slurry fertilizer on yield,nutrients uptake and quality of watermelon in the grav-el removal field were studied using watermelon cultivar Jincheng No.5 as the test crop.The results showed that the eco-nomic yield of watermelon was the highest under the treatment of water-soluble macronutrient fertilizer+biological bacterial manure,which was 51.4 t·hm-2.Water-soluble macronutrient fertilizer or it combined application of biological bacterial manure improved straw,fruit,and shoot nitrogen uptake of watermelon,while also significantly increased po-tassium uptakes in fruit and shoot.Nitrogen utilizationefficiency(31.2%)was highest by application of water-soluble macronutrient fertilizer,thus phosphorus(15.5%)and potassium(39.2%)utilization efficiencies were higher in treatment biogas slurry fertilizer.There is a significant and extremely significant positive correlation between total sugar,total ac-id,and vitamin C content in watermelon,respectively.Application of fertilizers improved atermelon quality,the obvious effects were in treatments water-soluble macronutrient fertilizer+biological bacterial manure.Therefore,comprehen-sive consideration of yield,nutrients uptake and quality of watermelon,it is high yield and quality by application of wa-ter-soluble macronutrient fertilizer or it combined application of biological bacterial manure in watermelon in the gravel removal field.