Influences of cervical high-risk human papilloma virus infection on vaginal microecological imbalance and expression of heparin binding epidermal growth factor and epidermal growth factor receptor
Objective To investigate the expression levels of serum heparin binding epidermal growth factor(HB-EGF)and epidermal growth factor receptor(EGFR)in patients with cervical high-risk human papilloma virus(HPV)infection,and the vaginal microecological imbalance condition.Methods A total of 169 patients with cervicitis who visited Shijiazhuang People's Hospital in Hebei Province from April 2020 to May 2022 were selected as the study subjects,they were divided into experimental group(88 cases,infected with high-risk HPV)and control group(81 cases,uninfected with high-risk HPV)according to whether they were infected with high-risk HPV.The clinical data of all patients were collected and sorted out.The high-risk HPV infection subtypes in the experimental group were detected;the distribution of vaginal flora and microecological balance status were detected and compared between the two groups;the expression levels of serum HB-EGF and EGFR were detected and compared.Spearman correlation analysis was applied to analyze the correlation between high-risk HPV infection and serum HB-EGF,EGFR levels and vaginal microecology.Logistic regression was used to analyze the influencing factors of high-risk HPV infection.Results The detection result of high-risk HPV infection showed that the detection rate of HPV 16 was the highest,followed by HPV18.The expression levels of serum HB-EGF and EGFR of patients in the experimental group were significantly higher than those in the control group(t=12.653,9.208,P＜0.05).The proportions of abnormal chlamydia,bacterial vaginitis,ureaplasma urealyticum,lactobacillus and the vaginal microecological imbalance in the experimental group were significantly higher than those in the control group(x2=6.396,5.581,8.025,4.254,9.433,P＜0.05).High-risk HPV infection was positively correlated with serum HB-EGF,EGFR expression levels,abnormal Chlamydia,Lactobacillus,bacterial vaginitis,and Ureaplasma urealyticum(r=0.382,0.417,0.376,0.516,0.449,0.391,P＜0.05).Abnormal lactobacilli,EGFR expression level,and HB-EGF expression level were the influencing factors of high-risk HPV infection(P＜0.05).Conclusions The serum HB-EGF and EGFR levels are up-regulated in patients with high-risk HPV infection,and high risk HPV infection can aggravate the vaginal microecological imbalance and increase the risk of cervical lesions.
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