Correlation analysis of assisted pregnancy outcomes in patients with low anti-Müllerian hormone levels in different age
Objective To analyze the effect of age on the outcome of assisted pregnancy in patients with anti-Müllerian hormone(AMH)＜1.1 ng/mL.Methods A total of 545 assisted pregnancy patients with low AMH who received in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET)in the First People's Hospital of Jining City from January 2020 to June 2022 were selected as study subjects.They were divided into group A(age≤35 years,n=218),Group B(35 years＜age＜40 years,n=139)and group C(age≥40 years,n=188)according to age.Baseline data,IVF/ICSI-ET related indicators and pregnancy outcomes were compared among the three groups.Results There was no significant difference in terms of duration of infertility,body mass index(BMI),AMH,dosage of basal follicle stimulating hormone(bFSH),basal luteinizing hormone(bLH),basal estradiol(bE2)and gonadotropin(Gn)between the three groups(P＞0.05).The number of antral follicles in Group A was significantly higher than that in Group B and Group C,with statistically significant differences(P＜0.05).The days of Gn,the number of punctured follicles and the number of retrieved eggs in Group A and Group B were significantly higher than that in Group C,with statistically significant differences(P＜0.05).There were no significant differences among the three groups in the rate of oocyte harvest,M Ⅱ egg,fertilization,cleavage,2PN and excellent embryo formation(P＞0.05),but the rate of excellent embryo blastocyst formation in Group A was significantly higher than Group B and Group C,with statistically significantly differences(P＜0.05).The rate of blastocyst formation,available blastocyst and available excellent blastocyst rate of Group A,Group B and Group C decreased successively,with statistically significant differences.The positive rate of human chorionic gonadotropin(HCG)and clinical pregnancy rate in Group A,Group B and Group C decreased successively,while the spontaneous abortion rate increased successively,with no statistical significance(P＞0.05),but the trend of decreasing and increasing were obvious.Conclusions In assisted pregnancy patients with low AMH,younger patients had better outcomes and were more likely to have successful pregnancy outcomes than older patients.
AgeAnti-Müllerian hormoneIn vitro fertilization-embryo transfer
万方数据
维普
