The predictive value of serum interleukin-10/tumour necrosis factor-α ratio for disease recurrence in patients with ovarian endometriosis after laparoscopic surgery
Objective To analyze the predictive value of serum interleukin-10(IL-10)/tumour necrosis factor-α(TNF-α)ratio for disease recurrence in patients with ovarian endometriosis(OEMs)after laparoscopic surgery.Methods A total of 223 patients with OEMs who were admitted to Tangshan Maternal and Child Health Hospital from January 2019 to December 2021 were selected as the study subjects,all of whom received conservative laparoscopic surgery,and were divided into recurrent group(n=27)and non-recurrent group(n=196)according to the disease recurrence after 1 year follow-up.The baseline information and laboratory indicators at the last examination before discharge were compared between the two groups,and the predictive value of serum IL-10/TNF-α ratio before discharge for disease recurrence in OEMs patients after laparoscopic surgery was analyzed.Results During the follow-up of 223 patients for 1 year,27 patients had disease recurrence,the recurrence rate was 12.11％.Compared with non-recurrent group,the maximum diameter of the lesion in the recurrent group before surgery was larger,revised-American society for reproductive medicine(r-ASRM)stage was higher,and the level of IL-10,TNF-α,IL-10/TNF-α ratio in the serum before discharge was higher(P＜0.05).The results of the receiver operating characteristic(ROC)curve of subjects showed that the area under the curve(AUC)of serum TNF-α before discharge to predict the recurrence of disease in patients with OEMs after laparoscopic surgery was 0.640,and the predictive value was low.The AUC of serum IL-10 and the ratio of IL-10/TNF-α before discharge to predict the recurrence of disease in patients with OEMs after laparoscopic surgery was 0.847 and 0.860,which had a certain predictive value,and the ratio of IL-10/TNF-α had a higher predictive value.Conclusions The ratio of serum IL-10/TNF-α before discharge is associated with the recurrence of disease in patients with OEMs after laparoscopic surgery,which can be used in the early prediction of postoperative disease recurrence.
万方数据
维普
