The expression levels and clinical significance of serum endotoxin and Toll like receptor 4 in patients with polycystic ovary syndrome
Objective To investigate the expression levels and clinical significance of serum endotoxin and Toll like receptor 4(TLR4)in patients with polycystic ovary syndrome(PCOS).Methods A total of 50 cases PCOS patients with menstrual disorder or previous ovulation detection indicating rare ovulation or even ovulation disorder admitted to Tangshan Maternal and Child Health Hospital from March to December 2021 were selected as the study group,and 50 non-PCOS patients who underwent physical examination in the same hospital during the same period were selected as the control group.The levels of serum endotoxin and TLR4 were detected by enzyme linked immunosorbent assay(ELISA).Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum endotoxin and TLR4 levels in PCOS.Results Compared with the control group,the levels of body mass index(BMI),serum endotoxin,TLR4,testosterone(T),luteinizing hormone(LH)and homeostatic model assessment of insulin resistance(HOMA-IR)in PCOS patients in the study group were significantly increased(P＜0.05).The area under the curve(AUC)of serum endotoxin and TLR4 in the diagnosis of PCOS was better than that diagnosed by them alone(Zcombination-endotoxin=1.992,Zcombination-TLR4=2.814,P＜0.05).Conclusions The serum levels of endotoxin and TLR4 increase significantly in PCOS patients.The combined detection of endotoxin and TLR4 has a high diagnostic value for PCOS.
Polycystic ovary syndromeEndotoxinToll like receptor 4Diagnosis
万方数据
维普
