Study on the application of preoperative dose-intensive carboplatin+paclitaxel therapy combined with extensive hysterectomy and pelvic lymph node dissection in locally advanced cervical cancer patients
Objective To explore the effect of preoperative dose-intensive carboplatin+paclitaxel(TC)treatment combined with extensive hysterectomy and pelvic lymph node dissection in the treatment of locally advanced cervical cancer.Methods A total of 100 locally advanced cervical cancer patients treated at Hebei Petro China Central Hospital from January 2020 to January 2022 were selected as the research subjects.According to the treatment plan ultimately selected by the patients,they were divided into an observation group(n=50)and a control group(n=50).Both groups received extensive hysterectomy and pelvic lymph node dissection,with the observation group receiving dose-intensive TC treatment before surgery and the control group receiving routine TC treatment before surgery.The perioperative indicators,chemotherapy efficacy,adverse reactions,world health organization on quality of life brief scale(WHOQOL-BREF)score,progression free survival time,and overall survival between two groups were observed and compared.Results The surgical time in the observation group was(210.03±41.16)minutes,which is significantly shorter than that in the control group(P＜0.05).There was no statistically significant difference(P＞0.05)between the observation group and the control group in terms of intraoperative bleeding volume,postoperative exhaust time,lymph node dissection,catheterization time,and postoperative hospitalization time.The observation group showed better chemotherapy efficacy than the control group,with an objective response rate(ORR)of 82.00％,significantly higher than the control group(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups(P＞0.05).After 3 months of treatment,the WHOQOL-BREF physiological field score in the observation group was(10.84±1.69)points,significantly higher than that in the control group(P＜0.05);there was no statistically significant difference in scores between the two groups in the fields of psychology,social relations,and environment(P＞0.05).The median progression free survival time in the observation group was 26.00 months(95％CI:23.37-28.64),significantly higher than that in the control group(P＜0.05).There was no statistically significant difference in median overall survival between the two groups(P＞0.05).Conclusions The combination of preoperative dose-intensive TC therapy with extensive hysterectomy and pelvic lymph node dissection has a good effect in the treatment of locally advanced cervical cancer,which can improve the quality of life and progression free survival time of patients.
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