The predictive value study of preoperative serum high density lipoprotein cholesterol and insulin-like growth factor-1 levels on the prognosis of patients undergoing radical prostatectomy
Objective To explore the predictive value of preoperative serum high density lipoprotein cholesterol(HDL-C)and insulin-like growth factor-1(IGF-1)on the prognosis of patients undergoing radical prostatectomy.Methods The clinical data of 90 patients with prostate cancer treated in Fuyang Hospital of Anhui Medical University from August2017 to October2021 were retrospectively analyzed,and the preoperative serum levels of HDL-C and IGF-1 were analyzed.The patients were followed up for one year after operation and prognosis condition were evaluated.The predictive value of preoperative serum HDL-C and IGF-1 levels on the prognosis of patients undergoing radical prostatectomy were analyzed.Results Of the 90 patients with radical prostatectomy,20 patients had poor prognosis,accounting for 22.22%.There were significant differences in serum IGF-1,HDL-C,total cholesterol,and fasting blood glucose levels in patients with different prognosis(P＜0.05).Logistic regression analysis showed that serum HDL-C and IGF-1 were prognostic factors in patients undergoing radical prostatectomy(P＜0.05).The receiver operating characteristic(ROC)curve showed that serum HDL-C and IGF-1 alone and in combination had certain predictive value for the prognosis of patients undergoing radical prostatectomy,and the combined predictive value was higher.Conclusions Serum HDL-C and IGF-1 can affect the prognosis of patients with radical prostatectomy,and the combined detection of serum HDL-C and IGF-1 before operation has high predictive value for the prognosis of patients with radical prostatectomy.
Radical prostatectomyHigh density lipoprotein cholesterolInsulin-like growth factor-1Prognosis
NETL
NSTL
万方数据
维普
