The relationship between homeobox gene A1 expression and clinicopathological characteristics and prognosis in patients with ovarian cancer
Objective To explore the relationship between homeobox gene A1(HOXA1)expression and the clinicopathological characteristics and prognosis in patients with ovarian cancer(OC)patients.Methods A total of 112 OC patients with underwent surgical treatment in Leshan Maternal and Child Health Hospital from November 2016 to November 2017 were selected as the study objects.Intraoperative excision OC tissue(OC group)and paracancer tissue(control group)were collected.The expression of HOXA1 in OC tissues and paracancer tissues was detected by quantitative real-time fluorescence quantitative polymerase chain reaction(qRT-PCR).The expression of HOXA1 in OC patients was detected by immunohistochemical staining.After 5 years of follow-up,the relationship between postoperative survival and HOXA1 expression in OC patients was analyzed.The factors of poor prognosis were analyzed by COX regression.Results Compared with the control group,the expression level of HOXA1 in OC group was significantly increased(P＜0.05).Compared with the control group,the HOXA1 positive expression rate in OC group was significantly increased(P＜0.05).The expression level of HOXA1 was correlated with tumor size,tumor differentiation,lymph node metastasis,and international federation of gynecology and obstetrics(FIGO)staging in OC patients(P＜0.05).The 5-year survival rate of HOXA1 positive expression group was lower than that of the negative expression group(P＜0.001).Lymph node metastasis and HOXA1 expression level were risk factors for poor prognosis of OC patients(P＜0.05).Conclusions The positive expression rate of HOXA1 in OC tissues was significantly increased,which was associated with the clinical characteristics and 5-year survival of OC patients.
NETL
NSTL
万方数据
维普
