Study of correlation between serum tumor necrosis factor-α/interleukin-10 ratio and neutrophil-to-lymphocyte ratio with postpartum glucose metabolism regression in patients with gestational diabetes mellitus
Objective To investigate the correlation between serum tumor necrosis factor-α(TNF-α)/interleukin(IL)-10 ratio and neutrophil-to-lymphocyte ratio(NLR)with postpartum glucose metabolism regression in patients with gestational diabetes mellitus(GDM).Methods A total of 112 GDM patients(GDMgroup)and 56 healthy pregnant women(control group)admitted to Sanya Maternal and Child Health Hospital from May 2020 to May 2022 were selected as study subjects.Serum TNF-α,IL-10,TNF-α/IL-10 ratio and NLR levels were compared between the two groups at late pregnancy.Univariate and multivariate Logistic regression models were used to identify the risk factors leading to abnormal glucose metabolism at 12 weeks postpartum in GDMgroup,and the predictive efficacy was evaluated.Results Compared with control group,TNF-α,TNF-α/IL-10 ratio and NLR levels were increased and the levels of IL-10 were decreased in GDMgroup(P＜0.05).Logistic regression analysis showed that pre-pregnancy body mass index(BMI)＞30 kg/m2,triglyceride(TG)≥5.69 mmol/L,oral glucose tolerance test(OGTT)1 h≥10.10 mmol/L,increased TNF-α/IL-10 ratio and increased NLR were all independent risk factors for abnormal glucose metabolism in the postpartum period(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that the area under ROC curve(AUC)of the combined diagnosis of TNF-α/IL-10 ratio and NLR was 0.896(95%CI:0.824-0.945),which was better than the single diagnosis of TNF-α,IL-10,TNF-α/IL-10 ratio and NLR(P＜0.05).Conclusions High levels of TNF-α/IL-10 ratio and NLR are risk factors for postpartum glucose metabolism abnormalities,and the combination tests can help to screen for postpartum glucose metabolism abnormalities in GDMpatients at an early stage.
NETL
NSTL
万方数据
维普
