Value assessment of prognosis of patients with locally advanced cervical cancer by analyzing systemic immune-inflammation index and systemic inflammation response index
Objective To investigate the effects of systemic immune inflammatory index(SII)and systemic inflammatory response index(SIRI)on the prognosis of locally advanced cervical cancer(LACC).Methods A total of 91 LACC patients who underwent radical surgery in Hengshui Maternal and Child Health Hospital from January 2016 to January 2018 were retrospectively selected as the patient group,and 40 healthy women from the same hospital during the same period were selected as the normal group.SIRI and SII were compared between the two groups,and the relationship between SIRI and SII and patients'clinical data was analyzed,and survival analysis was performed in the patient group.Results Compared with the normal group,SIRI and SII were significantly higher in the patient group,and the difference was statistically significant(P＜0.000,1).The proportion of patients with low differentiation,stage Ⅱ a2 and lymph node metastasis was higher in the high SIRI group than in the low SIRI group(P＜0.05),and the proportion of patients with lymph node metastasis was higher in the high SII group than in the low SII group(P＜0.05).The 5-year survival rates in both the high SIRI and high SII groups were lower than those in the low SIRI and low SII groups,and the differences were statistically significant(P＜0.05).The area under the curve for SIRI predictingpatients'1-,3-,and 5-year survival rates were 0.68,0.62,and 0.69,while the area under the curve for SII predicting patients'1-,3-,and 5-year survival rates were 0.61,0.66,and 0.67.Multi-factor Cox regression analysis revealed that the depth of mesenchymal infiltration and SIRI were independent factors affecting patients'5-year survival(P＜0.05).Conclusions Preoperative peripheral blood SIRI was an independent prognostic factor for LACC patients,and patients with high SIRI had a poor prognosis.
NETL
NSTL
万方数据
维普
