Clinical observation on the therapeutic effect of Bushen Huoxue Recipe on patients with diminished ovarian reserve of kidney deficiency and blood stasis type
Objective To observe the therapeutic effect of Bushen Huoxue Recipe on patients with diminished ovarian reserve(DOR)ofkidney deficiency and blood stasis type.Methods A total of 180 kidney deficiency and blood stasis type patients diagnosed with DOR admitted to Department of Traditional Chinese Medicine(TCM)Beijing Obstetrics and Gynecology Hospital were selected as study subjects.They were divided into estradiol tablets/estradiol and dydrogesterone tablets group(wesetern medicine group),Bushen Huoxue Recipe group(TCM group)and Bushen Huoxue Recipe combined with estradiol tablets/estradiol and dydrogesterone tablets group(combined group)by computer random grouping method,with 60 cases each.The changes of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),anti-Müllerian hormone(AMH),antral follicle count(AFC),ovarian volume,ovarian artery and uterine artery resistance index(RI)and endometrial thickness before and after treatment in the three groups were observed,and the TCM syndrome scores and therapeutic effects of three group were compared.Results A total of 11 patients(4 in western medicine group,3 in TCM group and 4 in combined group)withdrew from the study.After 6 months,FSH and LH were significantly decreased in all three groups,while E2 and AMH were increased(P<0.05).The FSH decreasing and E2 increasing were significant in western medicine group and combined group compared with TCM group(P<0.01).After treatment,the ovarian volume of the TCM group and the combination group increased(P<0.05),AFC was significantly increased(P<0.01),and ovarian artery RI significantly was decreased(P<0.01).The ovarian volume of western medicine group was not significantly increased(P>0.05),AFC was significantly increased(P<0.05),and ovarian artery RI was significantly decreased(P<0.05).There was no significant improvement in uterine artery RI in the three groups(P>0.05).Endometrial thickness increased significantly in all three groups(P<0.05),the increase of western medicine group and combined group was more significant than that of TCM group(P<0.01).After treatment,the TCM syndrome scores of the three groups were significantly reduced(P<0.05),and the decrease of TCM syndrome scores in TCM group and combined group was greater than that in western medicine group(P<0.05)compared with before treatment.The total effective rate was 71.43％ in western medicine group,82.46％ in TCM group,and 85.96％ in combined group.The efficacy of the combination group was better than that of the western medicine group(P<0.05).Conclusions Bushen Huoxue Recipe can produce good therapeutic effects on DOR patients by balancing hormone levels,promoting ovulation,and repairing the endometrium.Combined use of estradiol tablets/estradiol and dydrogesterone tablets may be an effective treatment strategy for DOR.
Diminished ovarian reserveBushen Huoxue RecipeKidney deficiency and blood stasis typeTraditional Chinese medicine therapy
NETL
NSTL
万方数据
维普
