Effects of male sex hormone and anti-Müllerian hormone level on the development of in vitro fertilization and embryo transfer embryos
Objective To investigate the effects of male sex hormone and anti-Müllerian hormone(AMH)levels on the development of in vitro fertilization-embryo transfer(IVF-ET)embryos.Methods The clinical data of 189 male patients who received IVF/intracytoplasmic sperm injection(ICSI)assisted pregnancy in Northwest Women and Children's Hospital from May 2015 to August 2021 were retrospectively analyzed.According to whether there were high-quality embryos in the fertilized eggs after 72 hours of fertilization,they were divided into high-quality embryos group and non-high-quality embryos group.The clinical data of the two groups were compared.The relevant factors affecting the formation of high-quality embryos were investigated through LASSO and Logistic regression models.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of sex hormone and AMH levels on embryonic development.Nomograph model was constructed and evaluated.Results Testosterone(T)level,estradiol(E2)level,sperm density,activity rate,sperm speed test index,fertility index and activity index of the non-high-quality embryo group were lower than those of the high-quality group(P＜0.05).The results of multivariable analysis showed that E2 level,T level,AMH level,sperm speed test index and fertility index were all independent influencing factors of the patient's embryonic development(P＜0.05).Compared with the single prediction of E2,T and AMH,the combined prediction efficiency of the three factors is significantly higher.The nomogram prediction model had high discrimination,accuracy and clinical applicability.Conclusions The abnormal changes of serum E2 level,T level and AMH level are closely related to the formation of non-high-quality embryos in male infertility patients.The combination of the three has high predictive value for the development of IVF-ET embryos,and can be used as a sensitive indicator for clinical screening of high-risk population.
Anti-Müllerian hormoneSex hormoneIn vitro fertilizationEmbryo transferEmbryonic development
万方数据
维普
