The diagnostic efficacy of thin-prep cytology test,high-risk human papilloma virus combined with serum squamous cell carcinoma antigen for cervical high-grade squamous intraepithelial neoplasia and above lesions
Objective To investigate the diagnostic efficacy of thin-prep cytology test(TCT),high-risk human papilloma virus(HR-HPV)combined with serum squamous cell carcinoma antigen(SCCA)in the diagnosis of high-grade squamous intraepithelial neoplasia(HSIL)+.Methods A total of 243 patients with cervical lesions admitted to Chizhou People's Hospital from January 2020 to October 2022 were selected as the research objects.All patients underwent TCT,HR-HPV,colposcopy biopsy histopathological examination and SCCA detection.The histopathological results were used as the gold standard to compare the diagnostic efficacy of TCT,HR-HPV,serum SCCA alone and combined detection for cervical HSIL+lesions.Results The histopathological examination results of 243 patients were:32 cases of low-grade squamous intraepithelial neoplasia(LSIL),173 cases of HSIL and 38 cases of cervical cancer.The positive rate of TCT was 72.43％,and the positive rate of HR-HPV was 83.54％.With the increase of cervical pathological grade,the positive rate of TCT and HR-HPV increased(P＜0.05).Serum SCCA positive were detected in 163 cases,the positive rate of serum SCCA and the expression of SCCA increased with the increase of cervical pathological grade(P＜0.05).The sensitivity,negative predictive value and accuracy of combined detection of TCT+HR-HPV+SCCA were higher than those of single detection and double-combined detection(P＜0.05).Conclusions The result of serum SCCA detection is positively correlated with cervical pathological grade,and combined with TCT and HR-HPV can improve the diagnostic efficacy of HSIL+.
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