Comparison of the efficacy of using dienogest versus combined oral contraceptive to control recurrence after ovarian endometrioma cystectomy
Objective To compare the clinical effects between dienogest(DNG)and combined oral contraceptive(COC)in long-term management after ovarian endometrioma cystectomy.Methods A total of 58 patients who underwent laparoscopic ovarian endometrioma cystectomy in Hubei Maternal and Child Health Hospital from February 2020 to August 2021 were selected as the study subjects and were treated with gonadotropin-releasing hormone agonist(GnRH-a)for 3 months after the operation.They were divided into DNG group(n=28)and COC group(n=30)by random number table method,and were treated with DNG and COC for 12 months respectively.The visual analog scale(VAS)score of dysmenorrhea,serum carbohydrate antigen 125(CA125),estradiol(E2),anti-Müllerian hormone(AMH),endometrioma recurrence condition,menstrual pattern,bone mineral density(BMD),adverse reactions and cost-effectiveness ratio(C/E)were compared between the two groups.Results There was no statistical significance differences in dysmenorrhea VAS score,CA125,AMH between the two groups(P＞0.05).E2,femoral and lumbar BMD in DNG group were higher than those in COC group(P＜0.05),there was no recurrence of endometrioma in both two groups.There was no significant difference in the total incidence of the adverse reactions between the two groups(P＞0.05).COC group has a lower C/E than that of DNG group(P＜0.05).Conclusions The effect of DNG on controlling the recurrence after ovarian endometrioma cystectomy is comparable to that of COC,but its influence on BMD and E2 may be less than that of COC,with a higher price than that of COC.
万方数据
维普
