Study on differences in levels of plasma soluble inflammatory markers between human immunodeficiency virus-infected patients receiving different anti-retroviral therapy regimen
Study on differences in levels of plasma soluble inflammatory markers between human immunodeficiency virus-infected patients receiving different anti-retroviral therapy regimen
Objective To investigate differences in the expression levels of soluble inflammatory markers in the plasma of human immunodeficiency virus(HIV)-infected patients receiving different anti-retroviral therapy(ART)regimen.Methods A total of 100 newly diagnosed HIV-infected patients in Hainan Provincial Hospital of Traditional Chinese Medicine from June 2019 to June 2021 were selected and randomly divided into non-nucleoside reverse transcriptase inhibitors(NNRTI)group and integrase strand transfer inhibitors(INSTI)groups,with 50 patients in each group.All patients were given emtricitabine tenofovir as the base drug,NNRTI patients were combined with efavirenz tablets,and INSTI patients were combined with raltegravir tablets.Patients were followed up before and 6 months after treatment,respectively.Blood biochemical indexes,T-cell count,virological indexes and inflammatory cytokines expression were compared between the two groups.Results After 6 months of treatment,there were significant differences in blood biochemical indexes,T-cell count,virological indexes and plasma inflammatory cytokine expression levels compared with those before treatment in the two groups(P＜0.05),and INSTI group patients had more significant changes in various indexes(P＜0.05).Conclusions Compared with NNRTI,the usage of INSTI is more helpful to reduce the inflammation levels in HIV-infected patients,and the drug has significant viral suppression effect.
关键词
人类免疫缺陷病毒/抗逆转录病毒治疗/非核苷类逆转录酶抑制剂/整合酶链转移抑制剂/炎性细胞因子
Key words
Human immunodeficiency virus/Anti-retroviral therapy/Non-nucleoside reverse transcriptase inhibitors/Integrase strand transfer inhibitors/Inflammatory cytokines
维普
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