Influence of anxiety and depression on immunological failure of antiviral therapy in acquired immune deficiency syndrome patients and analysis of psychological intervention strategies
Objective To analyze the influence of anxiety and depression on immunological failure of antiviral therapy(ART)in acquired immune deficiency syndrome(AIDS)patients and propose corresponding psychological intervention strategies.Methods The clinical data of 200 AIDS patients admitted to a hospital in Beijing and received antiviral treatment from February 2021 to February 2022 were retrospective analyzed.According to the immune response condition after antiviral treatment,they were divided into success group and failure group.Basic data and pre-treatment psychological state of the two groups were compared.Self-rating anxiety scale(SAS)and self-rating depression scale(SDS)scores of the two groups were counted.Univariate and multivariate Logistic regression was used to analyze the factors affecting the immunological failure of AIDS patients with antiviral therapy,and receiver operating characteristics(ROC)curve was drawn to analyze the clinical value of SAS and SDS scores and their combination in predicting the failure of immunological response to antiviral therapy in AIDS patients.Results The immunological failure rate of 200 AIDS patients after antiviral therapy was 21.00％(42/200).There were significant differences in gender,age,world health organization(WHO)clinical stage,medication compliance and whether anxiety and depression were combined between failure group and successful group(P＜0.05).Multivariate Logistic regression analysis showed that gender(male),age(≥60 years old),WHO clinical stage(Ⅲ/Ⅳ),medication compliance(non-compliance),anxiety and depression were the risk factors for the failure of immunological response to antiviral therapy in AIDS patients(OR＞1,P＜0.05).The SAS and SDS scores in the failure group were higher than those in the success group(P＜0.05).The ROC curve showed that the area under curve(AUC)of SAS score,SDS score and the combination of the two in predicting the immunological response failure of AIDS patients to antiviral therapy were 0.734,0.724 and 0.768,respectively.Conclusions Some AIDS patients still have immunological failure after antiviral treatment.The reasons are mainly related to gender,age,WHO clinical stage,medication compliance,anxiety and depression,and SAS score combined SDS score can effectively predict the failure of immunological response to antiviral treatment in AIDS patients.
万方数据
维普
