Effects of Qumei Decoction combined with doxycycline on immune inflammatory reaction and Toll-like receptor 2,forkhead box protein 3 mRNA of peripheral blood mononuclear cells in syphilis patients
Objective To explore the effects of Qumei Decoction combined with doxycycline on immune inflammatory response and Toll like receptor 2(TLR2),forkhead box protein 3(Foxp3)mRNA levels of peripheral blood mononuclear cells(PBMCs)in syphilis patients.Methods A total of 107 syphilis patients admitted to the Second Hospital of Xingtai from December 2017 to December 2021 were selected as study objects.Patients were divided into conventional group(n=53)and experimental group(n=54)by random envelope method.Conventional group were treated with doxycycline,while experimental group were treated with doxycycline combined with Qumei Decoction.The negative conversion rate of rapid plasma regain(RPR)test,clinical efficacy,T-lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),PBMCs TLR2 and Foxp3 relative mRNA expression and occurrence of adverse reactions of the two groups were compared.Results The RPR conversion rates at 3 and 6 months after treatment were higher in the experimental group than in the conventional group(P＜0.05).The total effective rate of treatment was higher in the experimental group than in the conventional group(P＜0.05).The CD3+,CD4+and CD4+/CD8+rates were higher in the experimental group than in the conventional group after 30 d of treatment(P＜0.05).After 30 d of treatment,the relative expression of TLR2 and Foxp3 mRNA in PBMCs was lower in the experimental group than in the conventional group(P＜0.05).The incidence of adverse reactions in the experimental group was lower than in the conventional group(P＜0.05).Conclusions Qumei Decoction combined with doxycycline can improve the conversion rate of syphilis patients with accurate efficacy and high safety,which may be related to the inhibition of TLR2 and Foxp3 expression of PBMCs.
SyphilisDoxycyclineQumei DecoctionT-lymphocyte subsetsRapid plasma regain test conversion rateAdverse reaction
万方数据
维普
