Analysis of the value of multiphase dynamic contrast-enhanced magnetic resonance imaging parameters combined with serum prostate specific antigen levels in predicting postoperative prognosis of prostatic cancer patients
Objective To analyze the value of multiphase dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters combined with serum prostate specific antigen(PSA)levels in predicting postoperative prognosis of prostatic cancer(PCa)patients.Methods The clinical data of 100 patients with PCa admitted to the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine from January 2015 to December 2021 were retrospectively analyzed.All patients underwent DCE-MRI examination before surgery,with volume transfer constant(Ktrans)and extracellular space volume ratio(Ve)recorded.Receiver operating characteristic(ROC)curves were drawn to evaluate the predictive value of DCE-MRI parameters combined with serum PSA levels for postoperative prognosis in patients with PCa.Results A total of 100 PCa patients who underwent surgical treatment were collected in this study,and a total of 23 cases(23.00％)experienced recurrence and metastasis during the follow-up period.There were statistically significant differences in TNM staging,Gleason score,serum PSA level,Ktrans and Ve value among PCa patients with different prognosis groups(P＜0.05).There was no statistically significant difference in age,body mass index(BMI),smoking history,and other clinical data among PCa patients in different prognostic groups(P＞0.05).The results of Logistic regression analysis showed that increased Ktrans and Ve value,upregulation of serum PSA expression,high TNM staging and Gleason score were risk factors for postoperative prognosis in PCa patients(OR＞1,P＜0.05).The ROC curve was drawn,and the area under curve(AUC)of DCE-MRI parameters(Ktrans,Ve value)and serum PSA alone and combination prediction of the prognosis of PCa patients were 0.877,0.753,0.721 and 0.939,respectively,all of which had certain predictive value,and combination prediction has the highest value.Conclusions The combination of DCE-MRI parameters and serum PSA levels has high application value in predicting the postoperative prognosis of PCa patients.DCE-MRI parameters can be used as an auxiliary means to evaluate the prognosis of PCa patients undergoing surgery.
Prostatic cancerMultiphase dynamic contrast-enhanced magnetic resonance imagingProstate specific antigenSurgeryPrognosis
万方数据
维普
