Value of alkaline phosphatase,lactate dehydrogenase and Gleason grades in evaluating the prognosis of low-risk metastatic hormone-sensitive prostate cancer
Objective To explore the value of alkaline phosphatase(ALP),lactate dehydrogenase(LDH)and Gleason grades in evaluating the prognosis of low-risk metastatic hormone-sensitive prostate cancer(mHSPC),and to provide scientific reference for the diagnosis and treatment of low-risk mHSPC patients.Methods A retrospective analysis was conducted on low-risk mHSPC patients in Lishui People's Hospital from 2015 to 2021,taking castration-resistant prostate cancer(CRPC)as the main outcome indicator of poor prognosis.48 patients with CRPC were included as the observation group,and 48 patients without CRPC were selected as the control group.The ALP,LDH and Gleason grades of the two groups were compared,and the predictive effects of ALP,LDH and Gleason grades on poor prognosis of mHSPC were analyzed by receiver operating characteristic(ROC)curve.Results ALP and LDH levels in observation group were significantly higher than those in control group,and the proportion of Gleason grade 4-5 patients in observation group was significantly higher than that in control group(P＜0.05).The area under curve of high ALP(≥300 U/L),high LDH(≥200 U/L)and high Gleason grades(4-5 grade)combination was 0.879,sensitivity was 92.1％specificity was 87.6％.Conclusions High ALP,high LDH and high Gleason grades are correlated factors with poor prognosis in low-risk mHSPC patients,and the combined use can provide an important reference for the clinical diagnosis and treatment of low-risk mHSPC patients.
万方数据
维普
