摘要
目的 探讨体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)后早期流产的相关影响因素.方法 选取2018年1月至12月中信湘雅生殖与遗传专科医院的6 107例经IVF/ICSI-ET治疗后成功妊娠患者作为研究对象,依据妊娠结局将患者分为早期流产组(n=987)和继续妊娠组(n=5 120),对比两组基线资料及临床指标,并采用二元Logistic回归分析探究早期流产的影响因素.结果 所有患者早期流产率为16.16％.单因素分析结果表明,两组年龄、窦卵泡数、移植后14d人绒毛膜促性腺激素(β-hCG)水平、基础抗米勒管激素水平、基础睾酮水平、不孕年限、助孕方式、不孕类型、有无染色体病及男方因素比较,差异具有统计学意义(P＜0.05).二元Logistic回归分析结果显示,年龄、移植后14 d β-hCG水平及助孕方式是IVF/ICSI-ET患者早期流产的影响因素.结论 高龄、移植后14 dβ-hCG水平低和冻胚移植的IVF/ICSI-ET患者会增加早期流产风险.
Abstract
Objective To investigate related influencing factors for early pregnancy loss(EPL)after in vitro fertilization/intra cytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET).Methods A total of 6,107 patients with successful pregnancy after IVF/ICSI-ET treatment in Reproductive and Genetic Hospital of CITIC-Xiangya from January to December 2018 were selected as study objects.According to the pregnancy outcomes,patients were divided into the EPL group(n=987)and continued pregnancy group(n=5,120).Baseline data and clinically indicators were compared between the two groups.The influencing factors for EPL were explored by binary Logistic regression analysis.Results The EPL rate of all patients was 16.16％.Univariate analysis showed that there were statistically significant differences between the two groups in age,antral follicle counts,β-human chorionic gonadotrophin(β-hCG)level at 14-day after transfer,basal anti-Müllerian hormone(AMH)levels,basal testosterone levels,infertility years,assisted pregnancy modes,infertility types,chromosome disease and male factors(P＜0.05).The results of binary Logistics regression analysis showed that age,β-hCG level at 14-day after transfer and assisted pregnancy modes were related factors to EPL in IVF/ICSI-ET patients.Conclusions IVF/ICSI-ET patients with older age,lower β-HCG at 14-day after transfer and frozen embryo transfer are at increased risk of EPL.
基金项目
湖南自然科学基金项目(2020JJ5992)
中信湘雅科研基金项目(YNXM-202220)
湖南创新型省份建设专项经费资助项目(2019SK4012)
维普
万方数据