Analysis of the relationship between serum soluble intercellular adhesion molecule-1 level and early abortion after in vitro fertilization-embryo transfer in patients with ovarian endometriosis and infertility
Objective To analyze the relationship between serum soluble intercellular adhesion molecule-1(sICAM-1)level and early abortion after in vitro fertilization-embryo transfer(IVF-ET)in patients with ovarian endometriosis(OEM)and infertility.Methods A total of 90 patients with OEM and infertility who received IVF-ET and had successful pregnancy in Haikou Mary Hospital from January 2020 to December 2022 were selected as the study subjects.They were divided into abortion group(n=17)and non-abortion group(n=73)according to the occurrence of early abortion after pregnancy.Baseline data and laboratory indicators were compared between the two groups,with emphasis on analyzing the relationship between serum sICAM-1 and early abortion after IVF-ET in patients with OEM and infertility.Results Compared with non-abortion group,the endometrial thickness on the day of transplantation in the abortion group was smaller,and the serum level of human chorionic gonadotropin-β(β-hCG)was lower on the 12-14 days after transplantation,while the serum level of sICAM-1 was higher(P＜0.05).Logistic regression analysis showed that endometrial thickness on the day of transplantation,serum β-hCG and sICAM-1 levels on the 12-14 days after transplantation were the influencing factors of early abortion after IVF-ET in OEM patients with infertility(P＜0.05).The receiver operating characteristic(ROC)curve showed that serum sICAM-1 had a certain predictive value for early abortion after IVF-ET in OEM patients with infertility.Conclusions The high level of sICAM-1 in serum indicates a higher risk of early abortion after IVF-ET in patients with OEM and infertility,and can be used as an auxiliary indicator for prediction of early abortion in patients.
万方数据
维普
