Correlation analysis between serum transforming growth factor β1 and spontaneous pregnancy failure in patients with salpingitic obstructive infertility after tubal dredging
Objective To investigate the correlation between serum transforming growth factor(TGF)β1 and spontaneous pregnancy failure in patients with salpingitic obstructive infertility(SOI)after tubal dredging.Methods A total of 305 SOI patients admitted to the Second Children & Women's Healthcare of Jinan City from January 2020 to January 2022 were selected as the study subjects.The level of serum TGF-β1 was detected before operation,and the natural pregnancy condition of the patients was followed up.The correlation between serum TGF-β1 level and natural pregnancy condition after tubal recanalization in SOI patients and its predictive value were tested by Point Biserial correlation,Logistic regression model and receiver operating characteristic(ROC)curve.Results A total of 8 cases were lost to follow-up.Of the 297 patients with SOI,113 cases(38.05％)had spontaneous pregnancy failure after surgery.There was a statistically significant difference in the natural pregnancy condition of SOI patients after surgery with different ages and infertility duration(P＜0.05).The spontaneous pregnancy failure rate in the high-level group of TGF-β1 was higher than that in the low-level group,with a statistical significant difference(P＜0.05).Point Biserial correlation analysis showed that there was a positive correlation between spontaneous pregnancy and serum TGF-β1 levels in patients with SOI after surgery(P＜0.05).Logistic regression analysis showed that after adjusting for age and infertility duration,taking low serum TGF-β1 levels as a reference,high serum TGF-β1 level was a risk factor for spontaneous pregnancy in patients with SOI after surgery.The ROC curve showed that preoperative serum TGF-β1 levels had a certain predictive value in predicting postoperative spontaneous pregnancy in patients with SOI(areas under curve=0.711,95％CI:0.650-0.772,P＜0.05).Conclusions There is a correlation between serum TGF-β1 level and spontaneous pregnancy rate in patients with SOI,which can be used as a predictor of spontaneous pregnancy risk.
万方数据
维普
