Effects of gonadotrophin-releasing hormone-antagonist regimen and progestin primed ovarian stimulation regimen on in vitro fertilization-embryo transfer pregnancy outcome in patients with diminished ovarian reserve
Objective To analyze the effects of gonadotrophin-releasing hormone-antagonist(GnRH-ant)regimen and progestin primed ovarian stimulation(PPOS)regimen on in vitro fertilization-embryo transfer(IVF-ET)pregnancy outcome in patients with diminished ovarian reserve(DOR).Methods A total of 176 DOR patients who received IVF-ET assisted pregnancy admitted to Tangshan Maternal and Child Health Hospital from October 2019 to October 2021 were selected as the study subjects and randomly divided into group A and group B,with 88 cases in each group.Group A received PPOS regimen for ovulation induction,while group B received GnRH-ant regimen for ovulation induction.The levels of sex hormones,ovulation status,and assisted pregnancy outcomes on the day of human chorionic gonadotropin(hCG)injection were compared between the two groups.Results Compared with group B,group A had higher levels of luteinizing hormone(LH)and estradiol(E2)on the day of hCG injection(P＜0.05).There were no significant difference in the levels of follicle stimulating hormone(FSH)and progesterone(P)in both groups(P＞0.05).The number of retrieved oocytes and available embryos in group A was more than that in group B(P＜0.05).There were no significant differences in the number of M Ⅱ oocytes and the rate of high-quality embryos between the two groups(P＞0.05).There were no significant differences in the cycle rate and successful embryo implantation rate of two groups of effective frozen thawed embryo transfer(FET)for assisted pregnancy outcomes(P＞0.05).Conclusions The effect of GnRH-ant regimen and PPOS regimen on IVF-ET pregnancy in DOR patients is similar,but the application of PPOS regimen is more conducive to improving ovulation of patients.
万方数据
维普
