Research progress of nitric oxide synthase 3 and interleukin-1 β gene polymorphisms and unexplained recurrent spontaneous abortion
Unexplained recurrent spontaneous abortion(URSA)is one of the most common pregnancy complications in obstetrics and gynecology,which causes serious negative effects on the patient's body,mind and family,and is a major threat to the reproductive health of women of childbearing age.The etiology and pathogenesis of URSA are still unclear,and there is no effective prevention and treatment measures,which is a major difficulty in the field of reproductive health.Studies have shown that single nucleotide polymorphism(SNP)in nitric oxide synthase 3(NOS3)and interleukin 1β(IL-1β)genes are associated with URSA,but the literature results are not consistent.This article reviews the research progress on the correlation between NOS3,IL-1 β gene polymorphisms and URSA.
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