Relationship between changes in T helper cell 17,hypoxic induction factor-1α levels and human papilloma virus infection in cervical squamous intraepithelial lesion and cervical cancer
Relationship between changes in T helper cell 17,hypoxic induction factor-1α levels and human papilloma virus infection in cervical squamous intraepithelial lesion and cervical cancer
Objective To discuss the relationship between changes in T helper cell 17(Th 17),hypoxic induction factor-1α(HIF-1α)and human papilloma virus(HPV)infection in cervical squamous intraepithelial lesion(SIL)and cervical squamous cell carcinoma(SCC).Methods The pathological tissues and venous blood of 40 patients with cervical SIL(SIL group)and 40 cervical SCC patients(SCC groups)from the Pathology Department of Jinzhai County People's Hospital from January 2020 to January 2023 were collected,and the normal cervical epithelium tissue and venous blood of 20 patients(control group)with general uterine resection were collected in the same hospital during the same period.Th17,HIF-1α levels and HPV-positive infection rates were detected and compared among the three groups.Results Th17 and HIF-1αlevels in SCC groups and SIL group were significantly higher than the control group(P＜0.05),and the SCC group was higher than the SIL group(P＜0.05).There were no statistical differences between SCC group and SIL group in single and multiple HPV infection rates(P＞0.05).Th17 and HIF-1α levels in HPV infection patients were significantly higher than those in uninfected patients(P＜0.05),and Th17 and HIF-1α were significantly higher in patients with multiple infection than patients with single infected(P＜0.05).Th17 and HIF-1α levels were significantly correlated with HPV infections(P＜0.05),and there are significant correlation between the two indicators(P＜0.05).Conclusions Th17 and HIF-1α levels can be used as the objective prediction indicators for SCC patients and references for clinical treatment.
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