免疫检查点T细胞激活抑制物免疫球蛋白可变区结构域、人内源性逆转录病毒-H长端重复相关蛋白2在子宫内膜癌中的表达及临床意义

扫码查看

原文链接

万方数据
维普

中文摘要：目的分析免疫检查点T细胞激活抑制物免疫球蛋白可变区结构域(VISTA)、人内源性逆转录病毒-H长端重复相关蛋白2(HHLA2)在子宫内膜癌(EC)中的表达及临床意义.方法选取2017年9月至2019年10月唐山市妇幼保健院收治的120例的EC患者作为研究对象,收集其的EC组织和癌旁正常组织.检测EC组织和癌旁正常组织VISTA、HHLA2的表达;采用Spearman分析免疫检查点VISTA、HHLA2的相关性;Kaplan-Meier分析VISTA、HHLA2与预后的关系;Cox回归分析影响EC患者预后的危险因素.结果 EC组织中VISTA、HHLA2阳性表达率显著高于正常癌旁组织(P＜0.05).Spearman相关性结果显示EC组织中VISTA与HHLA2表达呈正相关性(r=0.587,P＜0.05).EC组织中VISTA、HHLA2表达与临床病理特征有关(P＜0.05).Kaplan-Meier曲线结果显示VISTA阳性表达患者3年生存率低于阴性表达患者(x2=11.864,P＜0.05),HHLA2阳性表达患者3年生存率低于阴性表达患者(x2=4.975,P＜0.05).Cox回归分析结果显示VISTA和HHLA2是影响EC患者预后的危险因素(P＜0.05).结论免疫检查点VISTA、HHLA2在EC中高表达,其是影响EC预后的危险因素,二者可能是有价值的预后标志物.

外文标题：Expression and clinical significance of V-type immunoglobulin domain-containing suppressor of T cell activation,the immune checkpoint T-cell activation suppressor,and human endogenous retrovirus subfamily H long terminal repeat associating protein 2 in end

外文摘要：Objective To analyze the expression and clinical significance of V-type immunoglobulin domain-containing suppressor of T cell activation(VISTA),the immune checkpoint T-cell activation suppressor,and human endogenous retrovirus subfamily H long terminal repeat associating protein 2(HHLA2)in endometrial cancer(EC).Methods A total of 120 cases of EC patients admitted to Tangshan Maternal and Child Health Hospital from September 2017 to October 2019 were selected,and EC tissues and paracancerous normal tissues were collected.The expression of VISTA and HHLA2 in EC tissues and paracancerous normal tissues were detected.The correlation of immune checkpoints VISTA and HHLA2 was analyzed by Spearman analysis.Kaplan-Meier analysis was performed to analyze the relationship between VISTA,HHLA2 and the prognosis.Cox regression was performed to analyze the risk factors affecting the prognosis of EC patients.Results The positive expression rates of VISTA and HHLA2 in EC tissues were significantly higher than those in normal paracancerous tissues(P＜0.05).Spearman correlation showed a positively correlation between the expression of VISTA and HHLA2 in EC tissues(r=0.587,P＜0.05).The expressions of VISTA and HHLA2 in EC tissues were correlated with clinicopathological features(P＜0.05).Kaplan-Meier curve showed that the 3-year survival rate of patients with positive VISTA expression was lower than that of patients with negative expression(x2=11.864,P＜0.05),and the 3-year survival rate of patients with positive expression of HHLA2 was lower than that of patients with negative expression(x2=4.975,P＜0.05).Cox regression analysis showed that VISTA and HHLA2 were risk factors affecting the prognosis of EC patients(P＜0.05).Conclusions Immune checkpoint VISTA and HHLA2 are highly expressed in EC,they are risk factors affecting the prognosis of EC,and may be valuable prognostic markers.

外文关键词：

V-type immunoglobulin domain-containing suppressor of T cell activationHuman endogenous retrovirus subfamily H long terminal repeat associating protein 2Endometrial carcinomaPrognosis

作者：

柴静、张家弘、李梦雪

展开 >

作者单位：

唐山市妇幼保健院妇科,河北唐山 063000

关键词：

T细胞激活抑制物免疫球蛋白可变区结构域人内源性逆转录病毒-H长端重复相关蛋白2 子宫内膜癌预后

基金：

河北省2023年度医学科学研究课题计划

项目编号：

20231755

出版年：

2024

DOI：

10.3969/j.issn.1672-1993.2024.04.029

中国性科学

中国性学会

中国性科学

CSTPCD

影响因子：1.394

ISSN：1672-1993

年,卷(期)：2024.33(4)

参考文献量18