Advantages of Aptima human papilloma virus detection in primary screening of cervical precancerous lesions
Cervical cancer is the most common reproductive tract malignant tumor that threatens women's health.High-risk human papilloma virus(HR-HPV)infection is a prerequisite for precancerous lesions and invasive cervical cancer.In recent years,its incidence continues to rise,and infected patients are getting younger and younger,which not only threatens the physical health of female patients,but also has a huge negative impact on the psychology of female patients.Therefore,it is very important to improve the screening rate of cervical cancer in order to detect and interfere with the development of the disease as early as possible.HPV screening has also become a key strategy to identify cervical precancerous lesions and invasive cervical cancer.When HPV infection becomes persistent,the HPV genome will be integrated into the host cell genome,resulting in overexpression of E6 and E7,leading to genomic instability as well,resulting in cervical precancerous lesions and even cervical cancer in cervical tissues.At present,Aptima HPV detection is a quantitative test for HR-HPV E6/E7 mRNA expression,which can effectively evaluate the degree of E6/E7 oncogene activity in cervical epithelium.This paper mainly analyzes the advantages of Aptima HPV detection in the primary screening of cervical precancerous lesions,and reviews its related researches,in order to provide reference for the rational application of clinical HPV detection technology.
Cervical cancerHuman papilloma virusE6/E7 mRNACervical lesionCervical cancer screening
万方数据
维普
