Objective To investigate the expression of tripartite motif protein 29(TRIM29)in ovarian cancer tissue and its relationship with chemotherapy resistance.Methods A total of 86 cases of ovarian cancer tissues and corresponding adjacent tissues surgically removed in Danzhou People's Hospital from January 2019 to January 2021 were selected as the research subjects.The expression of TRIM29 was determined by immunohistochemistry.The relationship between TRIM29 expression and cisplatin chemotherapy resistance was analyzed.Results The expression of TRIM29 in cancer tissue was significantly higher than that in adjacent tissues(79.07％vs.4.65％,x2=10.216,P=0.001).The expression of TRIM29 in ovarian cancer tissues was related to international federation of gynecology and obstetrics(FIGO)stage,pathological grading,and lymph node metastasis(P＜0.05).The chemotherapy resistance of TRIM29 positive expression patients was 48.53％,which was higher than 11.11％in TRIM29 negative expression patients(x2=9.457,P=0.002).Cox regression analysis showed that FIGO staging,lymph node metastasis,and positive expression of TRIM29 were influencing factors of cisplatin chemotherapy resistance in ovarian cancer patients(P＜0.05).As of January 30,2023 following-up,the overall survival rate of TRIM29 positive expression patients was 72.10％,which was lower than 94.40％of TRIM29 negative expression patients(x2=3.873,P=0.049).Conclusions TRIM29 is highly expressed in ovarian cancer tissue,and positive expression of TRIM29 can significantly increase cisplatin chemotherapy resistance in ovarian cancer and indicate patient prognosis condition.
关键词
卵巢癌/顺铂/化疗耐药性/三结构域蛋白29
Key words
Ovarian cancer/Cisplatin/Chemotherapy resistance/Tripartite motif protein 29
维普
万方数据