Relationship between the levels of protein tyrosine phosphatase non-receptor type 3 and doublecortin-like kinase 1 in peripheral blood and the clinicopathological characteristics and prognosis of patients with ovarian cancer
Objective To investigate the relationship between the levels of protein tyrosine phosphatase non-receptor type 3(PTPN3)and doublecortin-like kinase 1(DCLK1)in peripheral blood and the clinicopathological characteristics and prognosis of patients with ovarian cancer(OC).Methods A total of 120 suspected OC patients admitted to Zhangjiakou First Hospital from May 2018 to May 2019 were selected as the study objects,60 patients diagnosed with OC by surgical pathological diagnosis were included in the OC group,and 60 patients diagnosed as benign by surgical pathological diagnosis were included in the benign group,and 60 women with healthy physical examination in the same hospital during the same period were included in the control group.According to the 3-year follow-up condition of OC patients,they were grouped into survival group(n=41)and death group(n=19).The levels of PTPN3 and DCLK1 in peripheral blood were detected by enzyme-linked immunosorbent assay(ELISA).Kaplan-Meier method was applied to analyze the relationship between PTPN3,DCLK1 and the prognosis of patients.COX regression analysis was applied to analyze the risk factors affecting the prognosis of OC patients.Results Compared with the control group,the levels of PTPN3 and DCLK1 in the peripheral blood of OC group and benign group increased significantly.Compared with the benign group,the levels of PTPN3 and DCLK1 in the peripheral blood of OC group increased significantly(P＜0.05).The expression levels of PTPN3 and DCLK1 were correlated with international federation of gynecology and obstetrics(FIGO)stage,lymph node metastasis and differentiation degree of OC patients(P＜0.05).The 3-year survival rate of patients with high expression of PTPN3 and DCLK1 was lower than that of patients with low expression group(P＜0.05).The levels of PTPN3 and DCLK1 in peripheral blood in death group were significantly higher than those in survival group(P＜0.05).Multivariate COX regression analysis showed that the degree of differentiation,high levels of PTPN3 and DCLK1 were the risk factors affecting the prognosis of OC patients(P＜0.05).Conclusions Expression levels of PTPN3 and DCLK1 in the peripheral blood of OC patients increased significantly,which is correlated with the survival status of OC patients three years after surgery.
Protein tyrosine phosphatase non-receptor type 3Doublecortin-like kinase 1Ovarian cancer
万方数据
维普
