Effect of ultra-long gonadotrophin-releasing hormone-agonist regimen during assisted reproduction on pregnancy outcomes in patients with adenomyosis
Objective To compare the effects of ultra-long gonadotrophin-releasing hormone-agonist(GnRH-ant)regimen and long GnRH-ant regimen during assisted reproduction on pregnancy outcomes in patients with adenomyosis.Methods A retrospective cohort study was conducted on 302 patients with adenomyosis who underwent assisted reproductive cycles(356 cycles in total)admitted to the First Affiliated Hospital of Hebei North University from February 2018 to October 2022.According to different treatment strategies,the patients were divided into an ultra-long GnRH-ant group(213 cycles)and long GnRH-ant group(143 cycles).The implantation rate,clinical pregnancy rate,live birth rate,miscarriage rate and others were compared between two groups.Results The levels of luteinizing hormone and estradiol on the day of human chorionic gonadotropin(hCG)in the ultra-long GnRH-ant group were lower than those in the long GnRH-ant group,and the number of oocytes retrieved was lower than that in the long GnRH-ant group(P＜0.05).The cancellation rate of fresh embryo transfer in the ultra-long GnRH-ant group was lower than that in the long GnRH-ant group(P＜0.05).The clinical pregnancy rate and live birth rate of the ultra-long GnRH-ant group were higher than those of the long GnRH-ant group(P＜0.05),and the early pregnancy miscarriage rate was lower than that of the long GnRH-ant group(P＜0.05).The clinical pregnancy rate and live birth rate of patients with diffuse adenomyosis in the ultra-long GnRH-ant group were significantly higher than those in the long GnRH-ant group(P＜0.05).Conclusions Compared with the long GnRH-ant regimen,using the ultra-long GnRH-ant regimen during assisted reproduction can better improve pregnancy outcomes in patients with adenomyosis,especially in patients with diffuse adenomyosis.
Ultra-long gonadotrophin-releasing hormone-agonist regimenAdenomyosisPregnancy outcomesRetrospective cohort study
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