Relationship between the content of Candida albicans enolase and vaginal microbiota,inflammatory factors,and efficacy in patients with candidal vaginitis
Objective To explore the relationship between the content of Candida albicans enolase and vaginal microbiota,inflammatory factors,and efficacy in patients with candidal vaginitis.Methods A total of 360 patients with candidal vaginitis treated in No.980 Hospital of Chinese PLA from January 2018 to December 2019 were collected as research subjects,and were grouped into an effective group(n=292)and an ineffective group(n=68)based on their efficacy.The levels of Candida albicans enolase,vaginal microbiota,and inflammatory factors in two groups were compared.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of Candida albicans enolase content on the efficacy of candidal vaginitis patients.Spearman rank correlation was applied to analyze the correlation between the contents of Candida albicans enolase and vaginal microbiota indicators in patients with candidal vaginitis.Pearson method was applied to analyze the correlation between the content of Candida albicans enolase and inflammatory factors levels in patients with candidal vaginitis.Results The content of Candida albicans enolase,the proportion of vaginal cleanliness of grade Ⅲ-Ⅳ,and inflammatory factors such as C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in the ineffective group higher than those in the effective group(P＜0.05),the proportions of the vaginal microbiota index pH value ≤ 4.5,and large amount of lactic acid bacteria were lower than those in the effective group(P＜0.05).The area under the curve(AUC)of Candida albicans enolase in predicting ineffective treatment in patients with candidal vaginitis was 0.775(95％CI:0.728-0.817),with an optimal cutoff value of 28.63 ng/mL,specificity of 86.30％,and sensitivity of 63.24％.The Spearman correlation analysis results showed that the content of Candida albicans enolase was correlated with the vaginal microecological indicators-pH value,lactobacilli,and vaginal cleanliness(P＜0.05).Pearson analysis showed that the content of Candida albicans enolase positively correlated with CRP(r=0.514,P＜0.001),PCT(r=0.482,P＜0.001),IL-6(r=0.578,P＜0.001),andTNF-α(r=0.231,P=0.018).Conclusions The content of Candida albicans enolase in patients with candidal vaginitis increase,and is closely related to vaginal microbiota,inflammatory factors,and efficacy.
万方数据
维普
