Interaction between sex hormone levels and human papilloma virus infection in evaluating patients'vaginal microbiota changes
Objective To explore the interaction between sex hormone levels and human papilloma virus(HPV)infection in evaluating patients'vaginal microbiota changes,providing insights for the diagnosis and treatment of vaginal microbiota dysbiosis.Methods A total of 49 female patients diagnosed with HPV infection in Hefei Second People's Hospital from February 2020 to February 2023 were selected as the patient group.Another 49 HPV-negative women undergoing examinations at the same hospital during the same period were selected as the control group.Levels of sex hormones(estradiol,progesterone,testosterone,follicle stimulating hormone,and luteinizing hormone)and changes in the vaginal microbiota(lactobacilli,anaerobes,bacillus,streptococci,E.coli,and Candida)were detected.The correlation between sex hormone levels and HPV infection and the relationship between changes in the vaginal microbiota and both sex hormone levels and HPV infection were analyzed.Results The levels of sex hormones in the patient group showed significant differences compared to the control group(P＜0.05),with decreased levels of estradiol,progesterone,and testosterone,and increased levels of follicle stimulating hormone and luteinizing hormone.Significant differences were also found in the vaginal microbiota between the patient group and the control group(P＜0.05),with a significant reduction in lactobacilli and increased levels of anaerobes,bacillus,streptococci,E.coli,and Candida.Sex hormone levels were negatively correlated with HPV infection(r=-0.56,P＜0.01),while the vaginal microbiota showed a positive correlation with sex hormone levels and HPV infection(r=0.63,P＜0.01).Conclusions Sex hormone levels and HPV infection interact to predict changes in the vaginal microbiota.Reduced sex hormone levels and HPV infection can lead to dysbiosis of the vaginal microbiota,thereby affecting reproductive health.
Sex hormonesHuman papilloma virus infectionVaginal microbiotaInteraction
万方数据
维普
