Relationship between the expression levels of G1/S-specific cyclin-D1,proliferating cell nuclear antigen and matrix metalloproteinase-9 and pathological features in endometrial hyperplasia tissues
Objective To explore the relationship between expression levels of G1/S-specific cyclin-D1(cyclinD1),proliferating cell nuclear antigen(PCNA),matrix metalloproteinase-9(MMP-9)and pathological features in endometrial hyperplasia tissues.Methods A total of 108 patients with endometrial hyperplasia admitted to Funan County Hospital of Traditional Chinese Medicine from February 2018 to March 2023 were retrospectively selected as study objects and analyzed.The expression levels of cyclinD1,PCNA and MMP-9 in endometrial hyperplasia tissues were detected.The pathological feature of patients'hyperplasia tissues were evaluated by pathological HE sections at the same time.Spearman correlation analysis was used to explore the correlation between cyclinD1,PCNA and MMP-9 levels and pathological features.Results Among 108 patients,73 patients(67.59％)had simple hyperplasia,24 patients(22.22％)had complex hyperplasia,and 11 patients(10.19％)had atypical hyperplasia.The number of complex hyperplasia patients with positive expression of cyclinD1,PCNA and MMP-9 was higher than that with simple hyperplasia.The number of atypical hyperplasia patients with positive expression of cyclinD1,PCNA and MMP-9 was significantly higher than that in patients with simple hyperplasia and complex hyperplasia,and the difference was statistically significant(P＜0.05).The results of Spearman correlation analysis showed that expression levels of cyclinD1,PCNA and MMP-9 were correlated with the pathological features of endometrial hyperplasia tissues.Conclusions The levels of cyclinD1,PCNA and MMP-9 are closely related to pathological characteristics in endometrial hyperplasia tissues.The high levels of above indicators suggest that patients are at high risk of precancerous lesions.
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