Effect of body mass index on in vitro fertilization and embryo transfer with long follicular stage and embryo transfer in infertile women with normal ovarian reserve
Objective To explore the effects of different body mass index(BMI)on pregnancy outcomes of in vitro fertilization and embryo transfer(IVF-ET)with long follicular stage and fresh transfer cycle in infertile women with normal ovarian reserve.Methods A total of 144 infertile women with normal ovarian reserve who underwent IVF-ET treatment for the first time in the Reproductive Center of Guilin Maternal and Child Health Hospital from January 1 to December 31,2022 were retrospectively selected as the study objects.According to the BMI of patients,they were divided into:normal group(18.0 kg/m2 ≤BMI＜24.0 kg/m2,n=87),overweight group(24.0 kg/m2≤BMI＜28.0 kg/m2,n=46),obese group(BMI ≥ 28 kg/m2,n=11).Male and female age,infertility years,anti-Müllerian hormone(AMH),gonadotropin(Gn)starting dose,Gn total dose,Gn days,average number of retrieved oocytes,2PN fertilization numbers,average number of embryos transferred,D3 high-quality embryo rate,pregnancy rate,early abortion rate and delivery rate were compared in each group.Results There were no significant differences in Gn days,average number of retrieved oocytes obtained,2PN fertilization numbers,average number of embryos transferred,D3 high-quality embryo rate,pregnancy rate,early abortion rate and delivery rate among the three groups(P＞0.05).However,with the increase of BMI,the pregnancy rate and delivery rate gradually decreased,and the early abortion rate gradually increased.The differences of Gn starting dose,Gn total dose among the three groups were statistically significant(P＜0.05).Conclusions The increase in BMI in infertile women undergoing IVF-ET may impact the ovulation induction response with long follicular stage,leading to an increase in Gn starting dose,Gn total dose,a decrease in pregnancy and delivery rates,and an increase in early abortion rates.
InfertilityIn vitro fertilization and embryo tranferBody mass index
万方数据
维普
