Correlation between serum soluble endoglin levels and early pregnancy abortion in women with recurrent spontaneous abortion
Objective To investigate the correlation between serum soluble endoglin(sEng)and early pregnancy abortion in women with recurrent spontaneous abortion(RSA).Methods A total of 197 RS A early pregnancy women who visited the Department of Obstetrics and Gynecology Hainan Women and Children's Medical Center from January 2021 to January 2023 were included as the RSA group,and 98 normal early pregnancy women who visited the same hospital during the same period were included as the normal early pregnancy group.The pregnancy outcomes before 13 weeks+6 of pregnancy were followed-up,and RSA group was divided into the RSA abortion group(n=66)and the RSA continued pregnancy group(n=131).The serum sEng levels of the three groups were compared and their correlation with early pregnancy abortion was analyzed.Results The abortion rate before 13+6 weeks in normal early pregnancy women was lower than RSA early pregnancy women(P＜0.05).The levels of D-dimer(D-D),interleukin-2(IL-2),tumor necrosis factor α(TNF-α),and sEng in the RSA abortion group were higher than those in the RSA continued pregnancy group and normal early pregnancy group,and the RSA continued pregnancy group was higher than that in the normal early pregnancy group(P＜0.05).Pearson linear correlation showed that serum sEng was positively correlated with D-D,IL-2,and TNF-α in RSA group(r＞0,P＜0.05).Logistic regression analysis showed that serum sEng level was associated with early pregnancy abortion in RSA women regardless of other factors mixed(P＜0.05).Conclusions The abnormal increase of serum sEng levels in RSA women may be related to early pregnancy abortion.The involved mechanisms may include endothelial cell damage,inflammation,and coagulation dysfunction.
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维普
