Changes of serum microRNA-26b and trimethylamine oxide expression in patients with gestational diabetes mellitus and their correlation with postpartum glucose metabolic abnormalities
Objective To investigate the changes of serum microRNA-26b(miR-26b)and trimethylamine oxide(TMAO)expression in patients with gestational diabetes mellitus(GDM)and their correlation with postpartum glucose metabolic abnormalities.Methods A total of 186 patients with GDM admitted to Haikou Maternal and Child Health Hospital were selected as the study objects.Oral glucose tolerance test(OGTT)was performed at 24-28 weeks of pregnancy,and the expressions of miR-26b and TMAO were detected.The patients were divide into abnormal group(n=52)and normal group(n=134)according to the OGTT at 6-8 weeks postpartum.Logistic multivariate analysis was used to analyze the relationship between miR-26b,TMAO expression and postpartum glucose metabolic abnormalities.Pearson correlation coefficient analysis was used to analyze the correlation between miR-26b and TMAO with postpartum fasting plasma glucose(FPG),fasting insulin(FINS)and homeostasis model assessment-insulin resistance(HOMA-IR)at 24-28 weeks.Results After adjusting for confounding factors,serum miR-26b and TMAO levels were still independently correlated with postpartum glucose metabolism abnormalities(P＜0.05).Postpartum FPG,FINS and HOMI-IR in abnormal group were higher than those in normal group(P＜0.05).MiR-26b was negatively correlated with postpartum FPG,FINS and HOMA-IR in abnormal group at 24-28 weeks,while TMAO was positively correlated with postpartum FPG,FINS and HOMA-IR(P＜0.05).Conclusions Serum miR-26b and TMAO of GDM patients express abnormally,and these abnormal conditions are closely related to postpartum glucose metabolic abnormalities.
万方数据
维普
