Effect of intravenous-inhalation anesthesia on surgery-related indicators of patients undergoing radical operation of ovarian cancer
Objective To investigate the effects of intravenous-inhalation anesthesia(ⅡA)on intraoperative signs,cerebral oxygen metabolic rate and immune function of patients undergoing radical operation of ovarian cancer(ROOC).Methods A total of 76 patients who underwent ROOC at Jianli People's Hospital from February 2021 to May 2022 were selected as the study subjects,and they were divided into total intravenous anesthesia(TIA)group and ⅡA group according to the anesthesia method,with 38 patients in each group.The TIA group received TIA,while the ⅡA group received ⅡA.The heart rate(HR),mean arterial pressure(MAP),cerebral oxygen metabolism indexes[cerebral blood flow/cerebral oxygen consumption(CBF/CMRO2),cerebral oxygen consumption/cerebral glucose consumption(CMRO2/CMRGlu)and lactic acid production(ADVL)]before anesthesia induction(T0),immediately after endotracheal intubation(T,),10 minutes after endotracheal intubation(T2)and at the end of surgery(T3)and various indexes of patients during anesthesia were compared between two groups,the T lymphocyte subsets before anesthesia at T0,T3,12 h after surgery and 24 h after surgery were compared between two groups.Results The anesthesia recovery time and spontaneous respiration recovery time in ⅡA group were significantly shorter than those in TIA group(P＜0.05).During operation,HR and MAP of the two groups were in normal fluctuation range,and there was no significant difference(P＞0.05).Compared with CBF/CMRO2,CMRO2/CMRGlu,and ADVL at T0 of patients in the ⅡA group were significantly increased at T1,T2 and T3(P＜0.05),and CBF/CMRO2 and ADVL of patients in TIA group were significantly increased(P＜0.05).The increase ranges of CBF/CMRO2 and ADVL of patients in ⅡA group were significantly lower than those in the TIA group(P＜0.05),and the increase range of CMRO2/CMRG1u was significantly greater than that in TIA group(P＜0.05).The levels of CD3+,CD4+and CD4+/CD8+of patients in ⅡA group were significantly higher than those in TIA group at the end of operation,12 h,24 h after operation(P＜0.05).Compared with at T0,the levels of CD3+,CD4+,and CD4+/CD8+of patients in the ⅡA group were significantly reduced at T3 and 12 h after operation.Compared with before anesthesia,the levels of CD3+,CD4+and CD4+/CD8+of patients in the TIA group were significantly reduced at T3,12 h after operation,and 24 h after operation(P＜0.05).Conclusions ROOC patients undergoingⅡA have a shorter awakening time and recovery time for autonomous respiration,and have a smaller impact on brain oxygen metabolism balance and immune related T lymphocyte subsets,with higher safety.
Radical operation of ovarian cancerIntravenous-inhalation anesthesiaBrain oxygen metabolism rateImmune function
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