Efficacy of Huang'e Capsule in the treatment of chronic prostatitis/chronic pelvic pain syndrome of Qi-stagnation and blood-stasis syndrome
Objective To investigate the efficacy and safety of Huang'e Capsule in treating chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)with Qi-stagnation and blood-stasis.Methods A total of 120 CP/CPPS patients with Qi-stagnation and blood-stasis admitted to Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Zhejiang Rongjun Hospital,Huzhou Traditional Chinese Medicine Hospital and Ningbo Traditional Chinese Medicine Hospital from July 2022 to July 2023 were selected as study objects.They were randomly divided into study group and control group,with 60 cases in each group.They were treated with Huang'e Capsule and α-blocker respectively.Both groups completed the national institutes of health chronic prostatitis symptoms index(NIH-CPSI)questionnaire(including three subitems with pain,urination symptoms,and quality of life)at baseline(0th week,before treatment),4th week,8th week(end of treatment),and 12th week(extended follow-up).The subitem scores and total scores of NIH-CPSI at baseline,4th week,8th week and 12th week were compared between two groups.The NIH-CPSI responses condition at 8th week and adverse events occurrence during treatment were compared between the two groups.Results At 8th week and 12th week,the NIH-CPSI pain subitem scores,quality of life subitem scores and total score of the study group were all lower than those of the control group(P＜0.05).At 8th week,NIH-CPSI response rate in the study group was higher than that in the control group(P=0.027).Compared with the non-responding group,the symptom duration of the responding group was slightly shorter,and the NIH-CPSI pain subtype,quality of life subitem scores and total score were higher,with statistical significance differences(P＜0.05).There was no significant difference in the occurrence of adverse events between study group and control group(P＞0.05).Conclusions The treatment of CP/CPPS patients with Huang'e Capsule can significantly improve the pain symptoms and quality of life in the short term,and there is still a certain tailing effect after the end of the 8-week course.
万方数据
维普
