Manual evolution and clinical significance of the World Health Organization laboratory manual for the examination and processing of human semen
Semen analysis is the cornerstone of male fertility evaluation.The World Health Organization(WHO)laboratory manual for the examination and processing of human semen is a worldwide recognized semen analysis guideline and provides the basis for standardization and reference values for senmen examination procedures worldwide.More than 40 years have passed since the first edition publication,during which the laboratory methods used to evaluate semen quality have changed significantly,with the improvement in the detection precision and accuracy.As andrology and reproductive medicine continue to progress,along with appearance and advancements in assisted reproductive technology,this manual undergoes regular updates to incorporate new,evidence-based testing methods.Beyond routine semen analysis,the evaluation of sperm function test is also essential to meet clinical needs.The sixth edition of the WHO manual,launched in 2021,provided up-to-date,evidence-based information on laboratory procedures required to assess male reproductive function,reproductive health,diagnosis and treatment of infertility.This article reviews and analyzes the evolution of the manual,emphasizes its updated content and clinical application relevance,hoping to be widely accepted and applied.
Semen analysisWorld Health OrganizationManual evolutionSemen parametersMale factor infertilitySperm function analysis
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