Mendelian randomization analysis related to male infertility and prostate cancer risk
Objective To investigate the causal relationship between male infertility and prostate cancer by two-sample Mendelian randomization(MR)method.Methods Based on the genome-wide association study(GWAS)data for male infertility and prostate cancer,MR analysis was performed using inverse variance weighting(IVW),the weighted median method(WM),and MR-Egger regression.The heterogeneity and horizontal pleiotropy of the results were assessed through the MR-Egger regression intercept test,Cochran's Q test,and the leave-one-out method.Results The IVW model indicated no causal relationship between male infertility and the risk of prostate cancer.No heterogeneity or horizontal pleiotropy was detected by the MR-Egger regression intercept test,Cochran's Q test,or the leave-one-out method.Conclusions This study found no clear evidence supporting a causal relationship between male infertility and the risk of prostate cancer.However,attention should still be paid to the impact of male infertility on high-grade prostate cancer.Further research is needed on the relationship between male infertility and prostate cancer,especially for high-grade prostate cancer.
Male infertilityProstate cancerMendelian randomization
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NSTL
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