Relationship between serum peroxisome proliferator-activated receptor γ coactivator 1α level and pregnancy outcome of in vitro fertilization and embryo transfer in patients with polycystic ovarian syndrome
Objective To explore the relationship between serum peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α)level and pregnancy outcome of in vitro fertilization and embryo transfer(IVF-ET)in patients with polycystic ovarian syndrome(PCOS).Methods From January 2021 to December 2022,99 PCOS patients who received IVF-ET treatment in Maternity and Child H ealth Care of Guangxi were selected as the study subjects.According to the pregnancy outcomes,the patients were divided into pregnancy group(n=49)and non-pregnancy group(n=50).The baseline data of all patients,as well as the levels of sex hormones and serum PGC-1α were collected and compared.Logistic regression analysis was used to analyze the risk factors for IVF-ET pregnancy outcomes in PCOS patients.And the predictive value of serum PGC-1α level on IVF-ET pregnancy outcomes in PCOS patients was evaluated using the receiver operating characteristic(ROC)curve.Results Among the 99 patients with PCOS,49 cases had successful pregnancies,with a success rate of 49.49％.The serum triglyceride(TG)and testosterone(T)levels in the non-pregnancy group were all higher than those in the pregnancy group,and the serum PGC-1α level was lower than those in the pregnancy group,with statistical significant differences(P＜0.05).Logistic regression analysis showed that high serum T and TG levels were risk factors for pregnancy outcome after IVF-ET treatment(OR＞1,P＜0.05),and high PGC-1α level was a protective factor for pregnancy outcome after IVF-ET treatment in PCOS patients(OR＜1,P＜0.05).ROC curve was drawn and displayed the area under curve(AUC)of serum PGC-1α level predicting IVF-ET pregnancy outcome in PCOS patients was 0.752(95％CI:0.654-0.850,P＜0.05),which had certain predictive value.When the Cut-off value of serum PGC-1α reached 0.485 ng/mL,the sensitivity and specificity of predicting IVF-ET pregnancy outcome in PCOS patients were 76％and 67％,respectively.Conclusions Serum PGC-1α level is related to IVF-ET pregnancy outcome in PCOS patients,and when its level reaches 0.485 ng/mL,the risk of pregnancy failure increases significantly,which has certain predictive value.In the future,it may be used as an auxiliary indicator to predict IVF-ET pregnancy outcome.
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