Clinical significance of transient receptor potential-canonical channel 3 and transient receptor potential-canonical channel 6 protein expression and correlation with progesterone resistance in patients with endometrial polyps
Objective To investigate the correlation between transient receptor potential-canonical channel 3(TRPC3)and transient receptor potential-canonical channel 6(TRPC6)protein expressions and progesterone resistance in endometrial polyps.Methods A total of 65 patients with endometrial polyps admitted to the Sixth Hospital of Shijiazhuang from February 2021 to February 2023 were collected as the endometrial polyp group,65 patients who underwent hysteroscopy due to infertility in the same hospital during the same period were regarded as the normal endometrial control group.Immunohistochemical methods were applied to detect the expression of TRPC3,TRPC6,and progesterone receptor(PR)proteins in endometrial polyp tissue and normal endometrial tissue;Spearman rank correlation was applied to analyze the correlation between TRPC3,TRPC6,and PR in endometrial polyp tissue;Logistic regression was applied to analyze the relevant influencing factors for the occurrence of endometrial polyps.Results The proportion of chronic endometritis and obesity between endometrial polyp group and normal endometrial control group had statistically significant differences(P＜0.05);compared with normal endometrial tissue,the positive expression rates of TRPC3 protein(56.92％vs.84.46％,x2=12.048,P=0.001)and TRPC6 protein(53.85％vs.83.08％,x2=12.861,P＜0.001)in endometrial polyp tissue increased,while the positive expression rate of PR protein(86.15％vs.46.15％,x2=23.224,P＜0.001)decreased.Spearman rank correlation analysis showed a negative correlation between TRPC3,TRPC6,and PR expression in endometrial polyp tissue(r=-0.289,-0.323,P＜0.05);TRPC3,TRPC6,chronic endometritis,and obesity were the influencing factors for the occurrence of endometrial polyps(P＜0.05).Conclusions The expressions of TRPC3 and TRPC6 in endometrial polyp tissue are negatively correlated with PR and are influencing factors for the occurrence of endometrial polyps.
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