Study on correlation between serum fibroblast growth factor 19,adisintegrin and metalloproteinase 12 levels and pregnancy outcomes in pre-eclampsia patients
Objective To detect the serum levels of fibroblast growth factor 19(FGF19),adisintegrin and metalloproteinase 12(ADAM12),and to explore the correlation between the two and the pregnancy outcomes in pre-eclampsia pregnant women.Methods A total of 90 pregnant women with pre-eclampsia in the People's Hospital of Dujiangyan from June 2019 to June 2022 were regarded as the pre-eclampsia group.According to the patient's condition,they were further grouped into a mild pre-eclampsia group(n=50)and a severe pre-eclampsia group(n=40).Another 90 healthy pregnant women who underwent pregnancy tests were selected as the control group.Patients with pre-eclampsia were grouped into a good pregnancy outcome group(n=59)and a poor pregnancy outcome group(n=31)according to follow-up results.The serum levels of FGF19 and ADAM 12 were detected by enzyme linked immunosorbent assay(ELISA);multivariate Logistic regression analysis was applied to analyze the influencing factors of adverse pregnancy outcomes in pre-eclampsia pregnant women;the predictive value of serum FGF19 and ADAM 12 on adverse pregnancy outcomes in pre-eclampsia pregnant women was evaluated by receiver operating characteristic(ROC)curve.Results Compared with the control group,the levels of serum FGF19 and ADAM 12 in pre-eclampsia group were significantly higher(P＜0.05);the levels of serum FGF19 and ADAM 12 in patients with severe pre-eclampsia were significantly higher than those in patients with mild pre-eclampsia(P＜0.05).Compared with the group with adverse pregnancy outcomes,the levels of serum FGF19 and ADAM 12 in the group with good pregnancy outcomes were significantly lower(P＜0.05).Logistic regression analysis showed that the high expressions of serum FGF19 and ADAM 12 were risk factors for adverse pregnancy outcomes in pregnant women with pre-eclampsia(P＜0.05).The area under curve(AUC)of serum FGF19 and ADAM12 in predicting pregnancy outcomes in pre-eclampsia patients was significantly larger than that of FGF19 and ADAM 12 prediction alone(P＜0.05).Conclusions The expression levels of FGF19 and ADAM 12 in serum of pregnant women with pre-eclampsia are high,which are closely related to the progression of patient's disease,and have clinical significance for early prediction of pregnancy outcomes.
Pre-eclampsiaFibroblast growth factor 19A disintegrin and metalloproteinase 12Pregnancy outcomeCorrelation
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