子痫前期患者血清FGF19、ADAM12水平与妊娠结局的相关性研究
Study on correlation between serum fibroblast growth factor 19,adisintegrin and metalloproteinase 12 levels and pregnancy outcomes in pre-eclampsia patients
姚雯 1任佳梅 1殷帆2
作者信息
- 1. 都江堰人民医院妇产科,四川都江堰 611830
- 2. 都江堰人民医院放射影像科,四川都江堰 611830
- 折叠
摘要
目的 检测血清成纤维细胞生长因子19(FGF19)、去整合素金属蛋白酶12(ADAM12)水平,并探讨两者与子痫前期孕妇妊娠结局的关系.方法 以2019年6月至2022年6月都江堰人民医院收治的90例子痫前期孕妇作为子痫前期组,根据患者病情进一步分为轻度组(n=50)和重度组(n=40);另取同期同院90例孕检健康的孕妇作为对照组.根据患者随访结果将子痫前期患者分为妊娠结局良好组(n=59)和妊娠结局不良组(n=31).本研究通过酶联免疫吸附试验(ELISA)法检测血清FGF19、ADAM12水平;利用多因素Logistic回归分析筛选影响子痫前期孕妇妊娠结局的危险因素;绘制受试者工作特征(ROC)曲线评价血清FGF19、ADAM12对子痫前期孕妇妊娠结局的预测价值.结果 子痫前期组血清FGF19、ADAM12水平均显著高于对照组(P＜0.05);重度组患者血清FGF19、ADAM12水平均显著高于轻度组(P＜0.05);妊娠结局良好组血清FGF19、ADAM12水平显著低于妊娠结局不良组(P＜0.05).Logistic回归分析表明,血清FGF19、ADAM12高表达是子痫前期孕妇不良妊娠结局的危险因素(P＜0.05).血清FGF19、ADAM12联合预测子痫前期患者妊娠结局的曲线下面积(AUC)显著大于FGF19、ADAM12单独预测(P＜0.05).结论 子痫前期孕妇血清FGF19、ADAM12表达水平较高,两者与患者疾病进展密切相关,对妊娠结局的早期预测具有临床意义.
Abstract
Objective To detect the serum levels of fibroblast growth factor 19(FGF19),adisintegrin and metalloproteinase 12(ADAM12),and to explore the correlation between the two and the pregnancy outcomes in pre-eclampsia pregnant women.Methods A total of 90 pregnant women with pre-eclampsia in the People's Hospital of Dujiangyan from June 2019 to June 2022 were regarded as the pre-eclampsia group.According to the patient's condition,they were further grouped into a mild pre-eclampsia group(n=50)and a severe pre-eclampsia group(n=40).Another 90 healthy pregnant women who underwent pregnancy tests were selected as the control group.Patients with pre-eclampsia were grouped into a good pregnancy outcome group(n=59)and a poor pregnancy outcome group(n=31)according to follow-up results.The serum levels of FGF19 and ADAM 12 were detected by enzyme linked immunosorbent assay(ELISA);multivariate Logistic regression analysis was applied to analyze the influencing factors of adverse pregnancy outcomes in pre-eclampsia pregnant women;the predictive value of serum FGF19 and ADAM 12 on adverse pregnancy outcomes in pre-eclampsia pregnant women was evaluated by receiver operating characteristic(ROC)curve.Results Compared with the control group,the levels of serum FGF19 and ADAM 12 in pre-eclampsia group were significantly higher(P＜0.05);the levels of serum FGF19 and ADAM 12 in patients with severe pre-eclampsia were significantly higher than those in patients with mild pre-eclampsia(P＜0.05).Compared with the group with adverse pregnancy outcomes,the levels of serum FGF19 and ADAM 12 in the group with good pregnancy outcomes were significantly lower(P＜0.05).Logistic regression analysis showed that the high expressions of serum FGF19 and ADAM 12 were risk factors for adverse pregnancy outcomes in pregnant women with pre-eclampsia(P＜0.05).The area under curve(AUC)of serum FGF19 and ADAM12 in predicting pregnancy outcomes in pre-eclampsia patients was significantly larger than that of FGF19 and ADAM 12 prediction alone(P＜0.05).Conclusions The expression levels of FGF19 and ADAM 12 in serum of pregnant women with pre-eclampsia are high,which are closely related to the progression of patient's disease,and have clinical significance for early prediction of pregnancy outcomes.
关键词
子痫前期/成纤维细胞生长因子19/去整合素金属蛋白酶12/妊娠结局/相关性Key words
Pre-eclampsia/Fibroblast growth factor 19/A disintegrin and metalloproteinase 12/Pregnancy outcome/Correlation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据