Correlation analysis between serum apolipoprotein A1,human lactate dehydrogenase A and fetal growth and development in patients with intrahepatic cholestasis of pregnancy
Objective To investigate the relationship between serum apolipoprotein A1(APOA1),lactate dehydrogenase A(LDHA)and fetal growth and development in patients with intrahepatic cholestasis of pregnancy(1CP).Methods A total of 128 1CP patients in Haikou Maternal and Child Health Hospital from January 2020 to August 2022 were selected as the observation group,and 64 healthy pregnant women received prenatal check-up in the same hospital during the same period were selected as the control group.Serum APOA1 and LDHA levels were detected in both groups.Observation group was divided into restricted group(n=27)and unrestricted group(n=101)according to the presence or absence of fetal growth restriction.The influencing factors of fetal growth restriction and the value of serum APOA1 and LDHA levels in the evaluation of fetal growth restriction were analyzed.Results Serum APOA1 level and fetal birth weight in observation group were lower than those in control group,and serum LDHA level was higher than those in control group(P＜0.05).Gestational age and serum APOA1 levels were independent protective factors for fetal growth restriction,and serum LDHA level was independent risk factor for fetal growth restriction(P＜0.05).The area under curve(AUC)value of the combined assessment of serum APOA1 and LDHA levels was 0.894,and it was higher than that of the separate assessment of serum APOA1 and LDHA levels.Conclusions The serum APOA1 and LDHA levels in ICP patients are closely related to fetal growth and development,and the detection of the two levels can provide a reference for early clinical assessment of the risk of fetal growth restriction.
Intrahepatic cholestasis of pregnancyApolipoprotein A1Lactate dehydrogenase AFetal growth restriction
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